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A new pathogen, previously unknown to the academic community, begins claiming lives in a city in Manila, Philippines. To uncover the cause, Dr. Jeong, Fuad, and Ji-suk, a team of researchers, venture into the undeveloped regions of the Philippines. However, they are captured by the indigenous people and subjected to various ordeals. Things take a dramatic turn when Ji-suk is forced into a marriage ceremony with the son of the tribal chief.